Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
Year: 2023
Type: dataset
Abstract: CD8+ T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8+ T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8+ T-cell culture induced potent effector differentiation, IFN-g production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8+ T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8+ T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8+ T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8+ T-cell effector function, with potential translation in cancer immunotherapy.
Authors: Scirgolea, Caterina, Sottile, Rosa, De Luca, Marco, Carnevale, Silvia, Puccio, Simone, Susanna, Alberto, Ferrari, Valentina, Scarpa, Alice, Scamardella, Eloise, Feno, Simona, De Paoli, Federica, Alvisi, Giorgia, Camisaschi, Chiara, De Simone, Gabriele, Basso, Gianluca, Giuliano, Desiree, Mazza, Emilia Maria Cristina, Gattinoni, Luca, Roychoudhuri, Rahul, Voulaz, Emanuele, Di Mitri, Diletta, Simonelli, Matteo, Losurdo, Agnese, Pozzi, Davide, Tsui, Carlson, Kallies, Axel, Barberis, Elettra, Manfredi, Marcello, Rescigno, Maria, Jaillon, Sebastien, Lugli, Enrico
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394021583