Plasma creatinine and oxidative stress biomarkers in amyotrophic lateral sclerosis
Year: 2020
Type: dataset
Abstract: Objective: To determine the associations between plasma creatinine (PCr), plasma uric acid (PUA), and urinary oxidative stress (OS) biomarkers with the ALSFRS-R at baseline and survival in a large epidemiological cohort study (ALS COSMOS) with a well-phenotyped patient population (N = 355). Methods: Fasting plasma and first void urine samples were obtained. PCr, PUA, urinary 8-oxo-deoxy guanosine (8-oxodG), and 15-F2t-isoprostane (IsoP) were analyzed at baseline, near the midpoint of follow-up, and at the final blood draw (before death or withdrawal from study). We estimated associations between these biomarkers and the ALSFRS-R at baseline and survival. Results: At baseline, PCr correlated with ALSFRS-R (Spearman r = 0.30), percent (%) FVC (r = 0.20), PUA (r = 0.37), and 8-oxodG (r = −0.13, all p p r = 0.29, midpoint: r = 0.23, final: r = 0.38, all p Conclusions: To date, PCr predicted survival the best, compared to PUA, 8-oxodG, and IsoP. Although PCr represents the degree of muscle mass, it may also represent complex biochemical changes in ALS. Because the field has no reliable prognostic biomarkers, the importance of PCr warrants further investigation through clinical studies in ALS.
Source: Figshare
Authors: Mitsumoto, Hiroshi, Garofalo, Diana C., Santella, Regina M., Sorenson, Eric J., Oskarsson, Björn, J Americo M. Fernandes Jr, Andrews, Howard, Hupf, Jonathan, Gilmore, Madison, Heitzman, Daragh, Bedlack, Richard S., Katz, Jonathan S., Barohn, Richard J., Kasarskis, Edward J., Lomen-Hoerth, Catherine, Tahseen Mozaffar, Nations, Sharon P., Swenson, Andrea J., Factor-Litvak, Pam
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394212973