Bioinformatics Identification and Validation of Aging‑Related Molecular Subtype and Prognostic Signature in Sarcoma
Year: 2023
Type: dataset
Abstract: Aging could regulate many biological processes in malignancies by regulating cell senescence. Consensus cluster analysis was conducted to differentiate TCGA sarcoma cases. LASSO cox regression analysis was performed to construct an aging-related prognostic signature. We identified two categories of TCGA-sarcoma with significant difference in prognosis, immune infiltration and chemotherapy and targeted therapy. Moreover, an aging-related prognostic signature was constructed for sarcoma, which had a good performance in predicting the 3-year and 5-year overall survival of sarcoma patients. We also identified a lncRNA MALAT1/miR-508-3p/CCNA2 regulatory axis for sarcoma. This stratification could provide more evidence for estimating prognosis and immunotherapy of sarcoma.
Source: Figshare
Authors: Hong, Xu, Liu, Hui, Chen, Chu, Lai, Tian, Lin, Jingui
Institutions: Karolinska Institutet, Nanjing Agricultural University, University of Science and Technology of China, Kunming Institute of Botany, Central South University, Shandong University, Northeast Agricultural University, University of Pittsburgh, The University of Western Australia, Anhui Medical University, Chinese Academy of Sciences, Changzhi Medical College, Brookhaven National Laboratory, Peking University, Huazhong Agricultural University, China University of Mining and Technology, Tianjin Medical University General Hospital, Tianjin Medical University Cancer Institute and Hospital, First Affiliated Hospital of Xinjiang Medical University, Wuhan University, Northwest University, Guangzhou Center for Disease Control and Prevention, Shanghai University of Traditional Chinese Medicine, Heilongjiang Provincial Academy of Agricultural Sciences, Nanfang Hospital, Xi'an Medical University, Nanjing Drum Tower Hospital, First Affiliated Hospital of Xi'an Jiaotong University, Yunnan Institute of Parasitic Diseases, Shanghai East Hospital, National Center for AIDS/STD Control and Prevention,China CDC, Sun Yat-sen University Cancer Center, Tang Du Hospital, Guizhou Provincial People's Hospital, National Institutes of Health Clinical Center, Baruch S. Blumberg Institute, Henan Agricultural University, Northeast Forestry University, Huazhong University of Science and Technology, Tianjin Medical University, Southern Medical University, Dali University, Shandong Agricultural University, Henan Normal University, Zhejiang University, Lanzhou University, Hainan Medical University, Michigan State University, South China University of Technology, The University of Texas at San Antonio Health Science Center, Fred Hutch Cancer Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394263144