Additional file 8 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
Year: 2022
Type: dataset
Abstract: Additional file 8. Exploratory drug screen results. (A) Detailed information about the 134 hit compounds identified in the exploratory screen. (B) BBB permeability for the 134 hit compounds identified in the exploratory screen, as determined by a literature search. Positive BBB qualities were found for 87 compounds (labeled in green), negative BBB qualities were found for 41 compounds (labeled in red), and no information was found for 6 compounds (labeled in yellow).
Source: Figshare
Authors: Johnson, Noah R., Wang, Athena C.-J., Coughlan, Christina, Sillau, Stefan, Lucero, Esteban, Viltz, Lisa, Markham, Neil, Allen, Cody, Dhanasekaran, A. Ranjitha, Chial, Heidi J., Potter, Huntington
Institution: University of Colorado Anschutz
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394396120