Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers
Year: 2021
Type: dataset
Abstract: LncRNAs belong to the type of noncoding RNA transcripts, which exceed 200 nucleotides in size. MALAT1 as one of the earlier identified lncRNAs in cancer is investigated by more and more scientific researchers. Expression, clinical significance and function of MALAT1 in pan-cancer exist as big difference. To detect the expression and clinical significance of MALAT1 gene precisely and comprehensively among different kinds of cancers, some classical databases such as GEPIA, TIMER, KM Plotter, and PrognoScan were fully applied. An immunological role of MALAT1 among different kinds of cancers was also determined in TIMER database. Our results showed that MALAT1 was differently expressed in different kinds of cancers using GEPIA, Oncomine, and TIMER databases to analyze. Especially, MALAT1 high RNA level was related to the early stage in lung and gastric cancer patients. MALAT1 expression was closely related to prognosis among different cancer patients. Furthermore, expression of MALAT1 was related to tumor immune cell infiltrating. Expression level of MALAT1 was also related to immune makers such as macrophage, T cell, NK cells, and so on. These findings indicate that MALAT1 could be a potential prognostic biomarker of some kinds of cancer and was significantly correlated with tumor-infiltrating immune cells in a wide variety of cancers.
Source: Figshare
Authors: Guo, Lili, Zhang, Xiuwen, Pan, Hongli, Li, Yang, Wang, Jing, Li, Lin, Dong, Yafang, Du, Xinxin, Chen, Jun, Guo, Fengjie
Institutions: Gansu Agricultural University, Henan University of Science and Technology, First Hospital of China Medical University, Fourth Affiliated Hospital of Guangxi Medical University, Jining Medical University, Tongji University, University of Science and Technology of China, Civil Aviation Administration of China, Johns Hopkins University, Minzu University of China, Sun Yat-sen University, Zhejiang University of Science and Technology, Henan University, Beijing University of Chinese Medicine, Yangtze University, Capital Medical University, South China Normal University, Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking University, Shanghai Normal University, Sichuan University, Fudan University, Beijing Normal University, Southwest Forestry University, China University of Mining and Technology, University of Michigan, Sir Run Run Shaw Hospital, Radboud University Medical Center, Chinese PLA General Hospital, Soochow University, Guizhou Center for Disease Control and Prevention, Shanghai University of Traditional Chinese Medicine, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Air Force Engineering University, Guangzhou Women and Children Medical Center, Fourth Hospital of Hebei Medical University, Hebei General Hospital, Affiliated Hospital of Jiangsu University, Zhujiang Hospital, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Helmholtz Centre for Infection Research, Zhongshan Hospital, The Affiliated Yongchuan Hospital of Chongqing Medical University, Xi'an University of Technology, Chinese Academy of Agricultural Sciences, China Animal Health and Epidemiology Center, Tianjin Hospital, Shenzhen Institutes of Advanced Technology, Third Affiliated Hospital of Sun Yat-sen University, Institute of Animal Sciences, Centre for Individualised Infection Medicine, Children's Hospital of Suzhou University, Center for Experimental and Clinical Infection Research, Jiangsu Province Hospital, Shandong Provincial QianFoShan Hospital, Huai'an University, Tongji Hospital, Chinese People's Liberation Army, Liaoning Cancer Hospital & Institute, Intuitive Surgical (United States), Qilu Hospital of Shandong University, Institute of Zoology, Northeast Forestry University, Huazhong University of Science and Technology, Southern Medical University, Shandong Agricultural University, Yangzhou University, Renmin University of China, Nanjing Medical University, Air Force Medical University, South China Agricultural University, Shihezi University, Griffith University, Inner Mongolia Agricultural University, Fujian Medical University, Ministry of Education of the People's Republic of China, Shanghai Medical College of Fudan University, The University of Texas MD Anderson Cancer Center, Shenyang Agricultural University, Central South University, Shandong University, Harbin Medical University, Hunan Normal University, Guangdong Medical College, Pfizer (United States), Shanghai University of Finance and Economics, Shanghai Jiao Tong University, The University of Texas at Arlington, Jilin University, Anhui Medical University, Huazhong Agricultural University, Cold Spring Harbor Laboratory, Wenzhou Medical University, Brown University, Shandong Normal University, First Affiliated Hospital of Xinjiang Medical University, University of Jinan, Zhengzhou University, West China Second University Hospital of Sichuan University, West China Hospital of Sichuan University, Fudan University Shanghai Cancer Center, Autism & Developmental Medicine Institute, Key Laboratory of Guangdong Province, BOE Technology Group (China), Jinan Central Hospital, Institute of Applied Ecology, Chaohu Hospital of Anhui Medical University, Institute of Vegetables and Flowers, First Hospital of Jilin University, The First Affiliated Hospital, Sun Yat-sen University, State Forestry and Grassland Administration, First Affiliated Hospital of Anhui Medical University, Sun Yat-sen University Cancer Center, Shuguang Hospital, Chongqing Public Health Medical Center, Second Affiliated Hospital of Zhejiang University, Liaocheng People's Hospital, Beijing Center for Disease Prevention and Control, Shanghai Municipal Center For Disease Control Prevention, National Institute of Metrology, First Affiliated Hospital of Jinan University, First Hospital of Lanzhou University, First Hospital of Xi'an, University of Chinese Academy of Sciences, Wuhan University of Science and Technology, Henan Agricultural University, New York University, Ocean University of China, Zhejiang University, Lanzhou University, Southeast University, Hainan Medical University, Vanderbilt University Medical Center, Tsinghua University, Tianjin University of Traditional Chinese Medicine, University of Leeds, Hong Kong Polytechnic University, Guiyang Medical University, Hunan University of Traditional Chinese Medicine, China Medical University, Guangdong Pharmaceutical University, Örebro University, Academy of Military Medical Sciences, Karolinska Institutet, Harbin University of Commerce, Second Affiliated Hospital of Chongqing Medical University, Ningxia Hui Autonomous Region Peoples Hospital, Affiliated Hospital of Guizhou Medical University, Nanjing Drum Tower Hospital, First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital of Wannan Medical College, Hunan Agricultural University, Beihang University, Chongqing Medical University, China Medical University, Hebei Normal University, Zhejiang Chinese Medical University, Uppsala University, Mayo Clinic, Jinan University, University of Pittsburgh, Tianjin Medical University General Hospital, Swedish University of Agricultural Sciences, Sun Yat-sen Memorial Hospital, Second Affiliated Hospital of Dalian Medical University, ShenZhen People’s Hospital, Guangdong Provincial Hospital of Chinese Medicine, Geriatric Research Education and Clinical Center, Gannan Medical University, Peking University People's Hospital, First Affiliated Hospital of Harbin Medical University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4394403326