Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
Year: 2019
Type: dataset
Abstract: Obesity triggers the genesis of non-alcoholic fatty liver diseases (NAFLD), which involves alterations of regulatory transcription networks and of hepatocyte-selective epigenomes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR)/ histone deacetylase 3 (HDAC3) complex, is a central component of such networks and accelerates the progression of NAFLD towards non-alcoholic steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout in mice alleviates the development of diet-induced steatosis and fibrosis and causes activation of lipid catabolic genes. Integrative cistrome, epigenome and transcriptome analysis identifies the lipid-sensing peroxisome proliferator-activated receptor alpha (PPARa, NR1C1) as a direct GPS2 target. Liver gene expression data from human patients reveal that GPS2 expression positively correlates with a NASH/fibrosis gene signature. Collectively, our data suggest that the GPS2-PPARa partnership in hepatocytes coordinates the progression of NAFLD in mice and in humans and thus might be therapeutically important.
Source: Figshare
Authors: Liang, Ning, Damdimopoulos, Anastasius, Goñi, Saioa, Giudici, Marco, Huang, Zhiqiang, Vedin, Lise-Lotte, Jakobsson, Tomas, Ahmed, Osman, Pedrelli, Matteo, Barilla, Serena, Alzaid, Fawaz, Mendoza, Arturo, Schröder, Tarja, Kuiper, Raoul, Parini, Paolo, Hollenberg, Anthony, Lefebvre, Philippe, Francque, Sven, Gaal, Luc Van, Staels, Bart, Venteclef, Nicolas, Treuter, Eckardt, Fan, Rongrong
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394410143