Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium
Year: 2020
Type: dataset
Abstract: Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analysed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 child and 1,962 adolescent whole-blood samples derived from ten cohorts. DNA methylation was measured using Illumina Infinium Methylation450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
Source: Figshare
Authors: Ronkainen, Justiina, Heiskala, Anni, Vehmeijer, Florianne O.L., Lowry, Estelle, Caramaschi, Doretta, Gutierrez, Guadalupe Estrada, Heiss, Jonathan A., Hummel, Nadine, Keikkala, Elina, Kvist, Tuomas, Kupsco, Allison, Melton, Phillip E., Pesce, Giancarlo, Soomro, Munawar H., Vives-Usano, Marta, Baiz, Nour, Binder, Elisabeth, Czamara, Darina, Guxens, Mònica, Mustaniemi, Sanna, London, Stephanie J., Rauschert, Sebastian, Vääräsmäki, Marja, Vrijheid, Martine, Ziegler, Anette-G., Annesi-Maesano, Isabella, Bustamante, Mariona, Huang, Rae-Chi, Hummel, Sandra, Just, Allan C., Kajantie, Eero, Lahti, Jari, Lawlor, Deborah, Räikkönen, Katri, Järvelin, Marjo-Riitta, Felix, Janine F., Sebert, Sylvain
Institutions: University of Oulu, Erasmus MC, Queen's University Belfast, University of Bristol, MRC Integrative Epidemiology Unit, Instituto Nacional de Perinatología, Icahn School of Medicine at Mount Sinai, Helmholtz Munich, Institute of Diabetes Research, Oulu University Hospital, Finnish Institute for Health and Welfare, University of Helsinki, Emory University, Columbia University, The University of Western Australia, Curtin University, Inserm, Institut Pierre Louis d‘Épidémiologie et de Santé Publique, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Max Planck Institute of Psychiatry, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, National Institutes of Health, National Institute of Environmental Health Sciences, The Kids Research Institute Australia, Universitat Pompeu Fabra, TUM Klinikum, Technical University of Munich, University of Turku, Imperial College London
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3200987377