Work

In vivo imaging of dendritic pruning in dentate granule cells

Year: 2016

Type: dataset

Abstract: Data files of the dendritic arbors fof all neurons used in analysis for the following publication: Gonçalves J.T., Bloyd C.W., Shtrahman M, Johnston S.T., Schafer S.T., Parylak S.L., Thanh T., Chang T., Gage F.H., In vivo imaging of dendritic pruning in dentate granule cells, Nature Neurosci., in press, doi:10.1038/nn.4301 (2016) Abstract:We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Source: Figshare

DOI: 10.6084/m9.figshare.3205273

Authors: J. Tiago Gonçalves, Bloyd, Cooper W, Shtrahman, Matthew, Johnston, Stephen T, Schafer, Simon T, Parylak, Sarah L, Tran, Thanh, Chang, Tina, Gage, Fred H

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4394480476

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