Work

CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy

Year: 2021

Type: dataset

Abstract: We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.

Source: Figshare

DOI: 10.6084/m9.figshare.14278163

Authors: Costa, Germano Carneiro, Rocha, Manoel Otávio Da Costa, Souza, Paulo Eduardo Alencar De, Melo, Diego Felipe SA, Moreira, Paula Rocha, Gollob, Kenneth John, Nunes, Maria Do Carmo Pereira, Walderez Ornelas Dutra

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4394521255

Cites:

Cited by:

Related to: 10