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FIGURE 4 from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Year: 2024

Type: other

Abstract: Triple indirect IF of crocidolite- and chrysotile-induced MMs from Bap1+/− mice. IF staining showing tumor cells as well as M1 and M2 macrophages in crocidolite- and chrysotile-induced MMs from 2 Bap1+/− mice. Histologic sections were subjected to triple indirect sequential IF using three different antibodies: WT1 to detect MM tumor cells (red circles; Red 555 fluorescence); CD11c to stain M1 macrophages (green circles; green 488 fluorescence); and CD163 marker to stain M2 macrophages (yellow circles; Cy5 yellow fluorescence).

DOI: 10.1158/2767-9764.25563844.v1

Authors: Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani, Hatice U. Osmanbeyoglu, Andres J. Klein-Szanto, Kathy Cai, Joseph R. Testa

Language: English

Topic: Occupational and environmental lung diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4394567423

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