Work

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia

Year: 2024

Type: article

Source: Nature Structural & Molecular Biology

DOI: 10.1038/s41594-024-01263-0

Authors: Yu-Chen Yen, Yong Li, Chun-Liang Chen, Thomas Klose, Val J. Watts, Carmen W. Dessauer, John J. G. Tesmer

Institutions: Purdue University West Lafayette, The University of Texas Health Science Center at Houston

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, Walther Cancer Foundation, Purdue University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke

Awards: Non-Opioids for Inflammatory Pain: Adenylyl Cyclase 1 as a Novel Target, Structural and Functional Characterization of the Regulation of Adenylyl Cyclase 5 by Gbg subunits, G2499798185, GPCR - Linked RhoGEFs in Tumor Growth and Metastasis, Structural and Functional Studies of Galphaq and Its Signaling Complexes, G3858817220, Non-opioids for inflammatory pain: Adenylyl cyclase 1 as a novel target, Cancer Center Support Grant, Regulation of Adenylyl Cyclase Signaling Pathways, Structure, function, and inhibition of G protein-coupled receptor kinases, G9000172862, Predoctoral Training in the Pharmacological Sciences, Regulation of Adenylyl Cyclase Signaling Pathways, Pharmacological validation of adenylyl cyclase 1 as a drug target for chronic pain, KATP Channels as Downstream targets of adenylyl cyclases during opioid tolerance and withdrawal, Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestins

OpenAlex ID: W4394577155

FWCI: 2.984

Cites: 55

Cited by: 22

Related to: 10