Work

FIGURE 2 from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Year: 2024

Type: other

Abstract: TIME of crocidolite-induced MMs from Bap1+/− mice. A, Serial sections of a crocidolite-induced MM from Bap1-mutant mouse stained with several different immune cell markers: CD3 (T cells; arrows); CD45R (B cells); F4/80 (macrophages; arrows); and NK1.1 (natural killer cells), clockwise starting from top left. B, Serial sections showing distribution of macrophages in granuloma and TIME of MM from Bap1+/− mouse exposed to crocidolite. Left, Proinflammatory CD11c-positive M1 macrophages. Right, Protumorigenic CD206-positive M2 macrophages. Blue circles, granulomatous lesions; red squares, MM tumor areas. Note numerous crocidolite fibers (yellow block arrows) in granulomatous lesions.

DOI: 10.1158/2767-9764.25563850.v1

Authors: Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani, Hatice U. Osmanbeyoglu, Andres J. Klein-Szanto, Kathy Cai, Joseph R. Testa

Language: English

Topic: Occupational and environmental lung diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4394579640

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