FuncPEP v2.0: An Updated Database of Functional Short Peptides Translated from Non-Coding RNAs
Year: 2024
Type: article
Abstract: Over the past decade, there have been reports of short novel functional peptides (less than 100 aa in length) translated from so-called non-coding RNAs (ncRNAs) that have been characterized using mass spectrometry (MS) and large-scale proteomics studies. Therefore, understanding the bivalent functions of some ncRNAs as transcripts that encode both functional RNAs and short peptides, which we named ncPEPs, will deepen our understanding of biology and disease. In 2020, we published the first database of functional peptides translated from non-coding RNAs-FuncPEP. Herein, we have performed an update including the newly published ncPEPs from the last 3 years along with the categorization of host ncRNAs. FuncPEP v2.0 contains 152 functional ncPEPs, out of which 40 are novel entries. A PubMed search from August 2020 to July 2023 incorporating specific keywords was performed and screened for publications reporting validated functional peptides derived from ncRNAs. We did not observe a significant increase in newly discovered functional ncPEPs, but a steady increase. The novel identified ncPEPs included in the database were characterized by a wide array of molecular and physiological parameters (i.e., types of host ncRNA, species distribution, chromosomal density, distribution of ncRNA length, identification methods, molecular weight, and functional distribution across humans and other species). We consider that, despite the fact that MS can now easily identify ncPEPs, there still are important limitations in proving their functionality.
Source: Non-Coding RNA
Authors: Swati Mohapatra, Anik Banerjee, Paola Rausseo, Mihnea P. Dragomir, Ganiraju C. Manyam, Bradley M. Broom, George A. Calin
Institutions: The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Scripps College, German Cancer Research Center, Humboldt-Universität zu Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charité - Universitätsmedizin Berlin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,046
Funders: U.S. Department of Defense, American Heart Association, Cancer Prevention and Research Institute of Texas, CLL Global Research Foundation, G. Harold and Leila Y. Mathers Foundation, Deutschen Konsortium für Translationale Krebsforschung, Berlin Institute of Health, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, National Institute of General Medical Sciences, Moonshot Research and Development Program
Awards: G111615301, G1125512807, G1128424379, G117012389, TRANSLATING NOVEL DISCOVERIES IN GASTRIC ADENOCARCINOMA BIOLOGY INTO THERAPEUTIC ADVANCES, G1306915299, G1468253849, G1548154123, G1573574303, G1901027039, G1943345356, G24587324, G3052628540, G3195654104, HORMONE REGULATION OF TUMOR MICROENVIRONMENT IN ESTROGEN RECEPTOR-POSITIVE BREAST CANCER BY EXTRACELLULAR VESICLE MICRORNAS, G3909086042, G3966651400, G4119534169, G4377847664, G4550465470, The Future of Cancer Research: Training Program for Basic and Translational Scientists, G5029760787, G5086248425, Protein-coding and non-coding RNA biomarkers for early detection of CLL, G5448560268, G5680656575, G5850682332, G6344965762, G6439468129, G6736661663, G6868315350, G7333532868, MicroRNAs as a Therapeutic Target to Reduce Microglial Activation after Post-Stroke Social Isolation, G7729361383, G7819741318, miR-155 targeted therapeutics for precision medicine in lung cancer, G788993117, G8086300830, G8274656085, G8942739721, Cancer Center Support Grant, SPORE in Brain Cancer
OpenAlex ID: W4394603603