Work

n‐Bu4NI/K2S2O8 Mediated Csp2−Csp2 Bond Cleavage – Transformylation from p‐Anisaldehyde to Primary Amides

Year: 2024

Type: article

Abstract: n‐Bu4NI/K2S2O8 mediated transformylation from p‐anisaldehyde to primary amides is reported. The mechanistic studies suggest the reaction occurs via a single electron transfer pathway. Based on the DFT electronic structure calculations of various reaction pathways, the most plausible mechanism involves the formation of a phenyl radical cation and an arenium ion as the key intermediates. It represents the first example where p‐anisaldehyde is employed as a formyl source via a non‐metal mediated Csp2−Csp2 bond cleavage.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202301505

Authors: Xiaochen Liu, Samual Hee, Netanel G. Sapir, Alvin Li, Jianbo Liu, Yu Chen

Institutions: Queens College, CUNY, The Graduate Center, CUNY, City University of New York

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze