EVPsort: An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles
Year: 2024
Type: article
Abstract: Extracellular vesicles and particles (EVPs) play a crucial role in mediating cell-to-cell communication by transporting various molecular cargos, with small non-coding RNAs (ncRNAs) holding particular significance. A thorough investigation into the abundance and sorting mechanisms of ncRNA within EVPs is imperative for advancing their clinical applications. We have developed EVPsort, which not only provides an extensive overview of ncRNA profiling in 3,162 samples across various biofluids, cell lines, and disease contexts but also seamlessly integrates 19 external databases and tools. This integration encompasses information on associations between ncRNAs and RNA-binding proteins (RBPs), motifs, targets, pathways, diseases, and drugs. With its rich resources and powerful analysis tools, EVPsort extends its profiling capabilities to investigate ncRNA sorting, identify relevant RBPs and motifs, and assess functional implications. EVPsort stands as a pioneering database dedicated to comprehensively addressing both the abundance and sorting of ncRNA within EVPs. It is freely accessible at https://bioinfo.vanderbilt.edu/evpsort/.
Source: Journal of Molecular Biology
Institutions: Vanderbilt University Medical Center, Vanderbilt University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,420
Awards: Mechanisms controlling distinct growth and functional characteristics of the perinatal and adult thymus, exRNA in colorectal carcinoma: biogenesis and function, Integrative Single-Cell Atlas of Host and Microenvironment in Colorectal Neoplastic Transformation, SPORE in GI Cancer, SPORE in Breast Cancer, Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma, G9000058738, Molecular and Cellular Basis for Digestive Diseases, Cancer Center Support Grant, Early to Late Events in Colorectal Neoplasia: Basic Biology to Clinical Implementation, Shaping of the Microenvironment in Colonic Pre-Cancer by Epithelia and Microbiota, Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal Cancer
OpenAlex ID: W4394685159