Work

Coordinating activation of endo‐lysosomal two‐pore channels and TRP mucolipins

Year: 2024

Type: article

Abstract: Two‐pore channels and TRP mucolipins are ubiquitous endo‐lysosomal cation channels of pathophysiological relevance. Both are Ca2+‐permeable and regulated by phosphoinositides, principally PI(3,5)P2. Accumulating evidence has uncovered synergistic channel activation by PI(3,5)P2 and endogenous metabolites such as the Ca2+ mobilizing messenger NAADP, synthetic agonists including approved drugs and physical cues such as voltage and osmotic pressure. Here, we provide an overview of this coordination. image

Source: The Journal of Physiology

DOI: 10.1113/jp283829

Authors: Yu Yuan, Dawid Jaślan, Taufiq Rahman, Franz Bracher, Christian Grimm, Sandip Patel

Institutions: University College London, Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, University of Cambridge, Fraunhofer Institute for Translational Medicine and Pharmacology

Language: English

Topic: Calcium signaling and nucleotide metabolism

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $5,140

Funders: Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, National Taiwan University, Medical Research Council, Biotechnology and Biological Sciences Research Council

Awards: G1131382084, G1245107021, Membrane contact sites between endolysosomes and the ER as novel hubs in Ca2+ signalling., G1579701519, G2274219585, G3221862683, G3354437248, G3768877961, Understanding polymodal gating of a lysosomal ion channel, G3916100709, G40717403, G5515288158, Switching the ion selectivity of an ion channel on demand, G6534012216, G7552089987

OpenAlex ID: W4394694050

FWCI: 1.05

Cites: 120

Cited by: 4

Related to: 10