Year: 2024
Type: review
Abstract: There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.
Source: Circulation Research
Institutions: Cleveland Clinic, University Medical Center of the Johannes Gutenberg University Mainz, University of Oklahoma Medical Center, University of Oklahoma Health Sciences Center, Case Western Reserve University, Boston University, Boston Medical Center, Houston Methodist, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1611425886, G3541864657, Diet-Environment Interactions in Inflammation, RADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATION, G5929062284, G8993135685, IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL, (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air Pollution, Atrial Fibrillation Post-GWAS: Mechanisms to Treatment, ACHIEVE GreatER: Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region
OpenAlex ID: W4394728248