Work

Wounding increases nuclear ploidy in wound-proximal epidermal cells of the Drosophila pupal notum

Year: 2023

Type: article

Abstract: pupal notum enlarged following nearby laser ablation. Measuring DNA content, we determined that nuclei within 100 µm of a laser-wound increased their ploidy to ~8C, consistent with one extra S-phase. These data indicate non-mitotic repair strategies are not exclusively utilized by quiescent tissues and may be an underexplored wound repair strategy in mitotic tissues.

Source: PubMed

DOI: 10.17912/micropub.biology.001067

Authors: James White, M. Shane Hutson, Andrea Page-McCaw

Institution: Vanderbilt University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Vanderbilt University, National Institute of General Medical Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1971342940, G277209784, Cell fusion and the role of syncytia in the response to epithelial damage