Year: 2024
Type: article
Abstract: Chimeric antigen receptor (CAR)-T cell therapy has shown potential in improving outcomes for individuals with hematological malignancies. However, achieving long-term full remission for blood cancer remains challenging due to severe life-threatening toxicities such as limited anti-tumor efficacy, antigen escape, trafficking restrictions, and limited tumor invasion. Furthermore, the interactions between CAR-T cells and their host tumor microenvironments have a significant impact on CAR-T function. To overcome these considerable hurdles, fresh methodologies and approaches are needed to produce more powerful CAR-T cells with greater anti-tumor activity and less toxicity. Despite advances in CAR-T research, microbial resistance remains a significant obstacle. In this review, we discuss and describe the basics of CAR-T structures, generations, challenges, and potential risks of infections in CAR-T cell therapy.
Source: Journal of Cellular Immunology
Authors: Muhammad Kalim, Rui Jing, Xin Li, Zhiwu Jiang, Ningbo Zheng, Ziyu Wang, Guo Wei, Yong Lu
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: The Unique Roles of Tumor-Specific Th9 Cells for Solid Tumor Eradication, G1515775422, G2249531695, P38 MAPK is a molecular switch that controls the acquired resistance in adoptive cell therapy, G3308451554, Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy, G400703787, G4954474887, Recruitment of Rising Stars, Decoupling acute toxicities and antitumor efficacy in adoptive cell therapy, Induction of autosis to overcome resistance in adoptive cell therapy for solid tumors, G97340082
OpenAlex ID: W4394772272