Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson
Year: 2024
Type: review
Abstract: This Special Issue (SI) of Environmental and Molecular Mutagenesis (EMM), entitled "Inspiring Basic and Applied Research in Genome Integrity Mechanisms," is to update the community on recent findings and advances on genome integrity mechanisms with emphasis on their importance for basic and environmental health sciences. This SI includes two research articles, one brief research communication, and four reviews that highlight cutting edge research findings and perspectives, from both established leaders and junior trainees, on DNA repair mechanisms. In particular, the authors provided an updated understanding on several distinct enzymes (e.g., DNA polymerase beta, DNA polymerase theta, DNA glycosylase NEIL2) and the associated molecular mechanisms in base excision repair, nucleotide excision repair, and microhomology-mediated end joining of double-strand breaks. In addition, genome-wide sequencing analysis or site-specific mutational signature analysis of DNA lesions from environmental mutagens (e.g., UV light and aflatoxin) provide further characterization and sequence context impact of DNA damage and mutations. This SI is dedicated to the legacy of Dr. Samuel H. Wilson from the U.S. National Institute of Environmental Health Sciences at the National Institutes of Health.
DOI: 10.1002/em.22595
Authors: Shan Yan, Shobhan Gaddameedhi, Robert W. Sobol
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,570
Awards: SON-mediated RNA splicing in glioblastoma, Measuring genomic DNA damage and DNA repair capacity in longitudinal population samples - a step towards precision prevention, Barcoded human cells engineered with heterozygous genetic diversity to uncover toxicodynamic variability, Greater Caribbean Center for Ciguatera Research, Greater Caribbean Center for Ciguatera Research, Mechanism of APE2 in genome integrity, Investigating genetic ancestry influences on oral cavity and laryngeal cancer survival disparities, The Paternal Age Effect - Enhanced Germ Cell Mutagenesis Modulated by the TRP53/APE1/MDM2 Tumor Suppressor Axis, A Systems Approach to Mapping the DNA Damage Response, ATM activation by DNA single-strand breaks, Mechanism of APE1 in DNA damage response, Stimuli-responsive mucin1-specific nanoparticles for efficacious combinatorial chemotherapy of pancreatic ductal adenocarcinoma, Circadian clock disruption: A risk factor for environmental carcinogenesis, Center for Human Health and the Environment (CHHE), New mouse model of cisplatin-induced AKI and development of prevention therapy
OpenAlex ID: W4394799141