Work

Directed-evolution approach to empower EGFR targeting for immunotherapy

Year: 2024

Type: article

Abstract: Advances in directed-evolution technologies are enabling new strategies to isolate binding proteins that recognize disease-associated states of a target protein. In this issue of Cell Reports Methods, Dobersberger et al. devised a yeast display-based selection scheme to discover proteins that engage the cancer-associated activated state of a receptor to enable design of safe and effective immunotherapies.

Source: Cell Reports Methods

DOI: 10.1016/j.crmeth.2024.100762

Authors: Bunyarit Meksiriporn, Jamie B. Spangler

Institutions: Johns Hopkins University, Johns Hopkins Medicine, King Mongkut's Institute of Technology Ladkrabang, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200