Stable “snow lantern-like” aggregates of silicon nanoparticles suitable as a drug delivery platform
Year: 2024
Type: article
Abstract: toxicity, and modulation of drug release. Dynamic light scattering, scanning electron microscopy, and cryogenic nitrogen adsorption isotherm measurements confirmed the overall size (210 nm), morphology, and pore size (14-16 nm) of the prepared materials. Agglomeration in phosphate-buffered saline (PBS) was minimized by PEGylation by a two-step grafting procedure that employed a primary amine linker. Finally, the release rate of a model drug, hydrocortisone, was evaluated with both PEGylated and pristine particles. Conclusively, these snow-lantern cCVD Si particles do indeed appear suitable for drug delivery.
Source: Nanoscale
DOI: 10.1039/d3nr05655d
Institutions: University of Oslo, University of California San Diego
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
Funders: National Science Foundation, Norges Teknisk-Naturvitenskapelige Universitet, Universitetet i Oslo, Norges Forskningsråd, University of California, San Diego, Materials Research Science and Engineering Center, Harvard University, Division of Materials Research, Materials Research Science and Engineering Center, University of California, San Diego
OpenAlex ID: W4394914263