Supplementary Figure S2 from First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors
Year: 2024
Type: supplementary-materials
Abstract: Monotherapy tumor control in late-line cholangiocarcinoma. Change in measurable tumor burden over time is shown for two patients with late-line cholangiocarcinoma demonstrating prolonged disease control achieved with monotherapy TPST-1120, including patient B who achieved multiple stable disease scans with serial shrinkage of tumor burden to a nadir of -13% by RECIST over a duration of 9.5 months on treatment. Prior systemic treatment for patient A included cisplatin/gemcitabine, an investigational multi-kinase inhibitor, and an investigational anti-PD-1, while patient B received carboplatin/taxol, gemcitabine, oxaliplatin/capecitabine, and an investigational anti-PD-1/indoleamine 2,3-dioxygenase 1 inhibitor combination. Both patients discontinued the most recent therapy regimen received prior to TPST-1120 treatment for progressive disease.
Authors: Mark Yarchoan, John D. Powderly, Bruno R. Bastos, Thomas B. Karasic, Oxana V. Crysler, Pamela N. Munster, Meredith A. McKean, Leisha A. Emens, Yvonne M. Saenger, Yasser Ged, Robert Stagg, Steven Smith, Chan C. Whiting, Anne Moon, Peppi Prasit, Yonchu Jenkins, Nathan Standifer, Thomas W. Dubensky, Sam H. Whiting, Susanna V. Ulahannan
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4394914951