Work

Synthetic soldiers: Turning T cells into immortal warriors

Year: 2024

Type: article

Abstract: The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20240258

Authors: Nicholas P. Restifo, Luca Gattinoni

Institutions: National Institutes of Health, National Cancer Institute, University Hospital Regensburg, Leibniz Institute for Immunotherapy, University of Regensburg

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4394917749