Work

Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner

Year: 2024

Type: article

Abstract: ABSTRACT: Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

Source: Blood

DOI: 10.1182/blood.2024024620

Authors: Aikaterini Karagianni, Anastasia Iris Karkempetzaki, Daniel Brooks, Shinobu Matsuura, Vrinda Dambal, Philip C. Trackman, Katya Ravid

Institutions: Boston University, University of Crete, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, The Forsyth Institute

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: The bone marrow extracellular matrix: scaffold of hematopoiesis, G5486846817, G8188488977, G9000099177, Center for Musculoskeletal Research

OpenAlex ID: W4394933639

FWCI: 0.579

Cites: 22

Cited by: 5

Related to: 10