Work

Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy

Year: 2024

Type: article

Abstract: We have investigated the impact of the late Na current ( INa,L) on cardiac and myocyte function with aging by using genetically engineered animals with enhanced or stabilized INa,L, due to phosphomimetic or phosphoablated mutations of Nav1.5. Our findings support the notion that phosphorylation of Nav1.5 at Ser571 prolongs myocardial repolarization and impairs diastolic function, contributing to the manifestations of the aging myopathy.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00325.2023

Authors: Emanuele Pizzo, Daniel O. Cervantes, Harshada Ketkar, Valentina Ripa, Drew M. Nassal, Benjamin Buck, Sreema P. Parambath, Valeria Di Stefano, Kanwardeep Singh, Carl I. Thompson, Peter J. Mohler, Thomas J. Hund, Jason T. Jacobson, Sudhir Jain, Marcello Rota

Institutions: New York Medical College, The Ohio State University Wexner Medical Center, The Ohio State University, Westchester Medical Center

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, New York Medical College, Università degli Studi di Parma, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute

Awards: Myocyte Repolarization and Cardiac Dysfunction with Age, Notch Signaling and Window of Opportunity for the Remodeling of the Infarcted Heart, Hypertension and inflammation: novel insights from human angiotensin type 1 receptor variants, Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophy

OpenAlex ID: W4394953208

FWCI: 2.137

Cites: 64

Cited by: 8

Related to: 10