Work

Author response: The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

Year: 2024

Type: peer-review

Abstract: Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.

Source: eLife

DOI: 10.7554/elife.88225.3.sa3

Authors: Mark S Lee, Peter J Tuohy, Caleb Y Kim, Philip P Yost, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns

Institution: University of Arizona

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4394963247

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