A novel DNase assay reveals low DNase activity in severe asthma
Year: 2024
Type: article
Abstract: We developed a new DNase assay and used it to show that DNase activity is impaired in asthma airways.
Authors: Annabelle R. Charbit, Maude A. Liegeois, Wilfred W. Raymond, Suzy A. A. Comhair, Mats W. Johansson, Annette T. Hastie, Eugene R. Bleecker, Merritt Fajt, Mario Castro, Kaharu Sumino, Serpil C. Erzurum, Elliot Israel, Nizar N. Jarjour, David T. Mauger, Wendy C. Moore, Sally E. Wenzel, Prescott G. Woodruff, Bruce D. Levy, Monica C. Tang, John V. Fahy
Institutions: University of California, San Francisco, Cleveland Clinic, University of Wisconsin–Madison, Wake Forest University Health Sciences, Wake Forest University, University of Arizona, University of Pittsburgh, Children's Hospital of Pittsburgh, University of Kansas, University of Kansas Medical Center, Washington University in St. Louis, Brigham and Women's Hospital, Harvard University, Pennsylvania State University
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Longitudinal Phenomics and Genetics of Severe Asthma, Stability of Severe Asthma Phenotypes: Impact of Exacerbations, Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma, Severe Asthma Research Program (SARP)-Washington University, Clinical Coordinating Center for the Severe Asthma Research Program (SARP), Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*, Exploring the biology of persistent type 2 airway niches in asthma, AMSA: ALXR/FBR Mediated Signaling in Severe Asthma, Clinical and Molecular Phenotypes of Severe Asthma, Evaluating the Impact of Metabolic Dysfunction on Asthma Pathology and Physiology, Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma, Phenotypic and biological features of mucus plugs in asthma
OpenAlex ID: W4395042074