Characterizing cognitive profiles in diverse middle‐aged and older Hispanics/Latinos: Study of Latinos‐Investigation of Neurocognitive Aging (HCHS/SOL)
Year: 2024
Type: article
Study design: Observational Study
Abstract: Introduction: We investigated cognitive profiles among diverse, middle-aged and older Hispanic/Latino adults in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) cohort using a cross-sectional observational study design. Methods: scores on SOL-INCA neurocognitive tests spanning domains of verbal memory, language, processing speed, and executive function. Results: Statistical fit assessment indices combined with clinical interpretation suggested five profiles: (1) a Higher Global group performing in the average-to-high-average range across all cognitive and instrumental activity of daily living (IADL) tests (13.8%); (2) a Higher Memory group with relatively high performance on memory tests but average performance across all other cognitive/IADL tests (24.6%); (3) a Lower Memory group with relatively low performance on memory tests but average performance across all other cognitive/IADL tests (32.8%); (4) a Lower Executive Function group with relatively low performance on executive function and processing speed tests but average-to-low-average performance across all other cognitive/IADL tests (16.6%); and (5) a Lower Global group performing low-average-to-mildly impaired across all cognitive/IADL tests (12.1%). Discussion: Our results provide evidence of heterogeneity in the cognitive profiles of a representative, community-dwelling sample of diverse Hispanic/Latino adults. Our analyses yielded cognitive profiles that may assist efforts to better understand the early cognitive changes that may portend Alzheimer's disease and related dementias among diverse Hispanics/Latinos. Highlights: The present study characterized cognitive profiles among diverse middle-aged and older Hispanic/Latino adults.Latent profile analysis of neurocognitive test scores was the primary analysis conducted.The target population consists of middle-aged and older Hispanic/Latino adults enrolled in the Hispanic Community Health Study/Study of Latinos and ancillary Study of Latinos - Investigation of Neurocognitive Aging.
DOI: 10.1002/dad2.12592
Institutions: California State University, San Marcos, Wayne State University, University of California San Diego, VA San Diego Healthcare System, San Diego State University, Albert Einstein College of Medicine, University of Illinois Chicago, Rush University Medical Center, University of North Carolina at Chapel Hill
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,310
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, Albert Einstein College of Medicine, Yeshiva University, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center on Minority Health and Health Disparities, National Institute on Minority Health and Health Disparities
Awards: G1042216835, G1064233440, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, G1587824183, G1666450717, G1917633662, G2135211244, G2135293100, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, G2575730562, G2644289446, G2970637568, G3062787641, Hispanic Community Health Study, G3677686024, G3838006641, G3952816605, G4121762840, Hispanic Community Health Study, G4552920371, G4860668542, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G6075306088, G6156511736, G6585687856, G6744188800, G7203655167, G7239480477, G7408420985, G8102260223, G820454163, G8840902395, G8904081916, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease, Culturally relevant contributors to cognitive and MRI changes in older Latinos, Semiparametric Regression Analysis of Interval-Censored Data in Current Cohort Studies
OpenAlex ID: W4395044751