Electrochemical Synthesis of C(sp 3 )‐Rich Amines by Aminative Carbofunctionalization of Carbonyl Compounds
Year: 2024
Type: article
Abstract: Alkylamines form the backbone of countless nitrogen-containing small molecules possessing desirable biological properties. Despite advances in amine synthesis through transition metal catalysis and photoredox chemistry, multicomponent reactions that leverage inexpensive materials to transform abundant chemical feedstocks into three-dimensional α-substituted alkylamines bearing complex substitution patterns remain scarce. Here, we report the design of a catalyst-free electroreductive manifold that merges amines, carbonyl compounds and carbon-based radical acceptors under ambient conditions without rigorous exclusion of air and moisture. Key to this aminative carbofunctionalization process is the chemoselective generation of nucleophilic α-amino radical intermediates that readily couple with electrophilic partners, providing straightforward access to architecturally intricate alkylamines and drug-like scaffolds which are inaccessible by conventional means.
Authors: Wen‐Qiang Liu, Boon Chong Lee, NingXi Song, Zhenghao He, Zi‐An Shen, Yixin Lu, Ming Joo Koh
Institution: National University of Singapore
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,510
Awards: G3869895980, G6686592665
OpenAlex ID: W4395045181