Synthetic human gonadal tissues for toxicology
Year: 2024
Type: review
Abstract: The process of mammalian reproduction involves the development of fertile germ cells in the testis and ovary, supported by the surrounders. Fertilization leads to embryo development and ultimately the birth of offspring inheriting parental genome information. Any disruption in this process can result in disorders such as infertility and cancer. Chemical toxicity affecting the reproductive system and embryogenesis can impact birth rates, overall health, and fertility, highlighting the need for animal toxicity studies during drug development. However, the translation of animal data to human health remains challenging due to interspecies differences. In vitro culture systems offer a promising solution to bridge this gap, allowing the study of mammalian cells in an environment that mimics the physiology of the human body. Current advances on in vitro culture systems, such as organoids, enable the development of biomaterials that recapitulate the physiological state of reproductive organs. Application of these technologies to human gonadal cells would provide effective tools for drug screening and toxicity testing, and these models would be a powerful tool to study reproductive biology and pathology. This review focuses on the 2D/3D culture systems of human primary testicular and ovarian cells, highlighting the novel approaches for in vitro study of human reproductive toxicology, specifically in the context of testis and ovary.
Source: Reproductive Toxicology
Authors: Toshiya Nishimura, Takanori Takebe
Institutions: The University of Osaka Premium Research Institute for Human Metaverse Medicine, The University of Osaka, Tokyo Medical and Dental University, Cincinnati Children's Hospital Medical Center, Advanced Medical Research Center, Yokohama City University, University of Cincinnati, Yokohama City University, University of Cincinnati Medical Center
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
Funders: Japan Agency for Medical Research and Development, Cincinnati Children’s Research Foundation, Japan Society for the Promotion of Science London, National Institutes of Health, Japan Society for the Promotion of Science, Japan Science and Technology Agency, National Institute of Diabetes and Digestive and Kidney Diseases, Core Research for Evolutional Science and Technology
Awards: G2487008325, G2494914395, Modeling monogenic steatohepatitis using human liver organoids, Engineering multi-organs in a dish, canine iPSC-derived urinary system via a cell competitive niche, G4757625745, G4982415599, Modeling diabetes using an integrated plate system, Inter-cellular RNA transfer-driven reprogramming, Organoid-guided Precision Hepatology for Steatohepatitis
OpenAlex ID: W4395052024