Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus
Year: 2024
Type: review
Abstract: The hippocampus is critical for memory and spatial navigation. The ability to map novel environments, as well as more abstract conceptual relationships, is fundamental to the cognitive flexibility that humans and other animals require to survive in a dynamic world. In this review, we survey recent advances in our understanding of how this flexibility is implemented anatomically and functionally by hippocampal circuitry, during both active exploration (online) and rest (offline). We discuss the advantages and limitations of spike timing-dependent plasticity and the more recently discovered behavioral timescale synaptic plasticity in supporting distinct learning modes in the hippocampus. Finally, we suggest complementary roles for these plasticity types in explaining many-shot and single-shot learning in the hippocampus and discuss how these rules could work together to support the learning of cognitive maps.
Source: Annual Review of Neuroscience
Authors: Zhenrui Liao, Attila Losonczy
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's Disease, Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the Hippocampus, G4222550140, Optimization, application and dissemination of high-speed hybrid multiphoton volumetric imaging technologies, G5088599194, G5299358466, G5510788794, Closed-loop intervention in epilepsy., Microcircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletion, Control of Axon Initial Segment in Epilepsy, Activity-dependent endocannabinoid control in epilepsy
OpenAlex ID: W4395445860