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Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment

Year: 2024
Type: article
Abstract: The December ESHRE Journal Club discussion focused on a study by Smits et al. (2023), the cellular and molecular implications of oxidative stress on oocyte aging, the factors that impair oocyte quality besides age, and the potential therapeutic strategies to mitigate oxidative stress and mitochondrial dysfunction in oocytes of advanced maternal age. AMA, advanced maternal age; GV, germinal vesicle oocyte; MI, metaphase I oocyte; ROS, reactive oxygen species; TCA, tricarboxylic acid cycle.
DOI: 10.1093/humrep/deae082
Authors: Omar F Ammar, Claudia Massarotti, Mina Mincheva, Kashish Sharma, George Liperis, Sonia Herraiz, Aida Rodríguez-Nuevo, Filippo Zambelli, Bettina P Mihalas, Juan J Fraire-Zamora
Institutions: University of Anbar, Ospedale Policlinico San Martino, University of Genoa, The University of Sydney, IVIRMA Global, Fundación IVI, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, UNSW Sydney
Language: English
Field: Medicine
Open Access status: bronze
OpenAlex ID: W4395699545
FWCI: 5.769
Cites: 38
Cited by: 14
Related to: 10