Work

Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights

Year: 2024

Type: article

Abstract: While FXR has shown promise in regulating bile acid synthesis and maintaining glucose and lipid homeostasis, undesired side effects have been observed in clinical trials. To address this issue, the development of intestinally restricted FXR modulators has gained attention as a new avenue for drug design with the potential for safer systematic effects. Our review examines all currently known intestinally restricted FXR ligands and provides insights into the steps taken to enhance intestinal selectivity.

Source: Molecules

DOI: 10.3390/molecules29092022

Authors: Amanda Morrison, Bahaa Elgendy

Institutions: University of Health Sciences and Pharmacy, Washington University in St. Louis

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,069