Year: 2024
Type: preprint
Abstract: Introduction Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities. Methods We analyzed the association of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) and modified CAIDE (mCAIDE) scores with dementia risk using logistic regression models stratified by race/ethnicity in NACC and ADNI, and assessed their interaction with APOE . Results Higher CAIDE scores were associated with an increased risk of dementia in Asian, Latinx, and NLW participants but not in Black participants. In contrast, higher mCAIDE scores were also associated with an increased risk of dementia in Black participants. Unfavorable mCAIDE risk profiles exacerbated the APOE *ε4 risk effect and attenuated the APOE *ε2 protective effect. Discussion Our findings underscore the importance of evaluating the validity of dementia risk scores in diverse populations for their use in personalized medicine approaches to promote brain health.
Source: medRxiv
Authors: Shea J. Andrews, Ana I. Boeriu, Michael E. Belloy, Alan E. Renton, Brian Fulton-Howard, Willa D. Brenowitz, Kristine Yaffe, the Alzheimer’s Disease Neuroimaging Initiative
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1049636575, G1058046096, G1075639496, G120189231, Alzheimer's Disease Research Center, G1369195717, G1593128567, G1859882300, G2190936067, 1Florida Alzheimer's Disease Research Center, G333817976, G3976056932, Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC), UAB Alzheimer's Disease Research Center, G5640525220, Alzheimer's Disease Neuroimaging Initiative, G639043084, New Mexico Alzheimer's Disease Research Center, Ancestry-specific effects of APOE on AD endophenotypes and risk factors, Vanderbilt Alzheimer's Disease Research Center, G8077616060, G9000000175, G9000044512, G9000059605, G9000073912, G9000082286, G9000087139, G9000198119, G9000208313, G9000224607, G9000271511, G9000331231, G9000332211, Boston University Alzheimer's Disease Research Center, Yale Alzheimer Disease Research Center, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease, Michigan Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Research Center (KU ADRC), Alzheimer's Disease Research Center, Oregon Alzheimer's Disease Research Center, Alzheimer's Disease Research Center, UC Davis Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Indiana Alzheimer's Disease Research Center, Cleveland Alzheimers Disease Research Center, New Approaches to Dementia Heterogeneity, Stanford Alzheimer's Disease Research Center, Mayo Alzheimer's Disease Research Center, University of Washington Alzheimer's Disease Research Center, Duke/UNC Alzheimer's Disease Research Center, Wisconsin Alzheimer's Disease Research Center, University of Kentucky Alzheimer's Disease Research Center, NORTHWESTERN Alzheimer's Disease Research Center, Penn Alzheimer's Disease Research Center (ADRC), Alzheimer's Disease Research Center, Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omics, South Texas Alzheimer's Disease Center, Goizueta Alzheimer's Disease Research Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Rush Alzheimer's Disease Research Center
OpenAlex ID: W4396239253