Glycemic Control, Cognitive Aging, and Impairment Among Diverse Hispanic/Latino Individuals: Study of Latinos– Investigation of Neurocognitive Aging (Hispanic Community Health Study/Study of Latinos)
Year: 2024
Type: article
Abstract: OBJECTIVE: Hispanic/Latino individuals in the U.S. have the highest prevalence of undiagnosed and untreated diabetes and are at increased risk for cognitive impairment. In this study, we examine glycemic control in relation to cognitive aging and impairment in a large prospective cohort of middle-aged and older Hispanic/Latino individuals of diverse heritages. RESEARCH DESIGN AND METHODS: Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is a Hispanic Community Health Study/Study of Latinos (HCHS/SOL) ancillary study. HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability sampled prospective cohort study. SOL-INCA enrolled 6,377 diverse Hispanic/Latino individuals aged 50 years and older (2016-2018). The primary outcomes were cognitive function, 7-year cognitive decline, and mild cognitive impairment (MCI). The primary glycemia exposure variables were measured from fasting blood samples collected at HCHS/SOL visit 1 (2008-2011). RESULTS: Visit 1 mean age was 56.5 years ± 8.2 SD, and the average glycosylated hemoglobin A1C (HbA1c) was 6.12% (43.5 ± 14.6 mmol/mol). After covariate adjustment, higher HbA1c was associated with accelerated 7-year global (b = -0.045; 95% CI -0.070; -0.021; in z score units) and executive cognitive decline and a higher prevalence of MCI (odds ratio 1.20; 95% CI 1.11; 1.29). CONCLUSIONS: Elevated HbA1c levels were associated with 7-year executive cognitive decline and increased MCI risk among diverse middle-aged and older Hispanic/Latino individuals. Our findings indicate that poor glycemic control in midlife may pose significant risks for cognitive decline and MCI later in life among Hispanic/Latino individuals of diverse heritages.
Source: Diabetes Care
DOI: 10.2337/dc23-2003
Institutions: University of California San Diego, Wayne State University, San Diego State University, University of Miami, University of Illinois Chicago, Albert Einstein College of Medicine, Rush University Medical Center, University of North Carolina at Chapel Hill, University of California Davis Medical Center, University of California, Davis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, University of Illinois at Urbana-Champaign, Albert Einstein College of Medicine, Yeshiva University, University of Illinois at Chicago, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1081972346, G1086382119, G1155380102, G1312369436, G1318449938, Hispanic Community Health Study, G1455175283, G1666450717, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1818487580, G1845395357, G1984718218, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2494211023, G2528054427, G2644289446, G2651066328, G2655143993, G2866617920, G2970637568, G308844681, G3259176005, Hispanic Community Health Study, G3614733703, G3722034730, G4196558080, G432753757, Hispanic Community Health Study, G4421869008, San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program, G5015503974, G5102588038, SDSU FUERTE: Faculty United towards Excellence in Research and Transformational Engagement, G528357465, G5365244667, G543802643, G5785169696, G596642789, G6075306088, G6088185517, G6149955053, G61781031, G6202424770, G6290268315, G639301372, G6405494218, G646921540, G7132511053, G7685783422, G820454163, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8987601928, G9000020291, G9000114775, G9000217254, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Culturally relevant contributors to cognitive and MRI changes in older Latinos, G937084196
OpenAlex ID: W4396498676