Work

Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse?

Year: 2024

Type: review

Abstract: High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. Here we review the role of nuclear factor erythroid 2-related factor 2 (Nrf2), an important and widespread antioxidant and anti-inflammatory transcription factor that may contribute to the pathogenesis and maintenance of cardiovascular diseases. We review studies showing that downregulation of Nrf2 exacerbates heart failure, hypertension, and autonomic function. Finally, we discuss the potential for using Nrf2 modulation as a therapeutic strategy for cardiovascular diseases and autonomic dysfunction.

Source: Physiology

DOI: 10.1152/physiol.00015.2024

Authors: Neha Dhyani, Changhai Tian, Lie Gao, Tara L. Rudebush, Irving H. Zucker

Institutions: University of Nebraska Medical Center, University of Kentucky

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, Hubbard Family Foundation