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Supplemental Figure 6 from Broad Next-Generation Integrated Sequencing of Myelofibrosis Identifies Disease-Specific and Age-Related Genomic Alterations

Year: 2024

Type: supplementary-materials

Abstract: Supplemental Figure 6. Gene expression in Ras pathway mutant MF. Panel A shows the heatmap of differentially expressed genes in a comparison of mutant Ras pathway MF vs wild type Ras pathway. Nine upregulated genes were identified. Panel B shows the gene expression differences in a volcano plot. Panel C is the gene set enrichment analysis of CD34 enriched MF samples with and without Ras mutations. Ras pathway and PI3K pathway were upregulated in MF patients that harbor mutant Ras pathway genes.

DOI: 10.1158/1078-0432.25728713.v1

Authors: Malathi Kandarpa, Dan Robinson, Yi-Mi Wu, Tingting Qin, Kristen Pettit, Qing Li, Gary Luker, Maureen Sartor, Arul Chinnaiyan, Moshe Talpaz

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4396543665

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