Supplementary Figures S1-S16 from Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Figure 1: Additional overview of screen and quality control. Supplementary Figure 2: Combination benefit in combination-cell line pairs. Supplementary Figure 3: Biomarkers of single agent and combination activity. Supplementary Figure 4: Combination activity of venetoclax plus AZD5991 in AML cell lines. Supplementary Figure 5: Combination activity by cancer type for AZD5991 + AZ3202. Supplementary Figure 6: Venetoclax + selumetinib and AZD5991 + selumetinib activity by cancer type. Supplementary Figure 7: Venetoclax + selumetinib and AZD5991 + selumetinib activity by cancer type. Supplementary Figure 8: Effect of MEK1/2 plus BCL2 inhibition on cell viability in AML cells. Supplementary Figure 9: Effect of MEK1/2 plus MCL1 inhibition on cell viability in AML cells. Supplementary Figure 10: Cancer type selectivity of venetoclax + AZD2811. Supplementary Figure 11: Effect of Aurora kinase B or pan Aurora kinase plus BCL2 inhibition on cell viability in DLBCL cell lines. Supplementary Figure 12: network analysis of AZD2811 plus venetoclax biomarkers and targets, and cancer type selectivity of AZD5991 + AZD5363. Supplementary Figure 13: Further analysis of capivasertib (AZD5363) plus AZD5991 in endometrial cell lines. Supplementary Figure 14: Effect of pan AKT inhibition plus MCL1 inhibition on cell viability in endometrial cell lines. Supplementary Figure 15: Further analysis of capivasertib (AZD5363) plus AZD5991 and other inhibitors in endometrial cell lines. Supplementary Figure 16: Effect of MCL1 genetic knockdown plus pan AKT inhibition on cell viability in endometrial cancer cell lines.
Authors: Azadeh C. Bashi, Elizabeth A. Coker, Krishna C. Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F. Jenkins, Dieudonne van der Meer, James T. Lynch, Syd Barthorpe, Courtney L. Andersen, Simon T. Barry, Alexandra Beck, Justin Cidado, Jacob A. Gordon, Caitlin Hall, James Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D. Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S. Willis, Wanjuan Yang, Mark J. O'Connor, Ultan McDermott, Susan E. Critchlow, Lisa Drew, Stephen E. Fawell, Jerome T. Mettetal, Mathew J. Garnett
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4396562210