Work

Impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell disease

Year: 2024

Type: article

Abstract: ABSTRACT: Serial cardiovascular magnetic resonance evaluation of children and young adults with SCD who underwent hematopoietic cell transplantation showed mean ECV, representing diffuse myocardial fibrosis, decreased 3.4% from baseline to 12 months posttransplantation. This trial was registered at www.clinicaltrials.gov as #NCT04362293.

Source: Blood

DOI: 10.1182/blood.2023023028

Authors: Akshay Sharma, Subodh Selukar, Yu Bi, Anthony Merlocco, Cara E. Morin, Chris Goode, Parul Rai, Jeffrey A. Towbin, Jane S. Hankins, Stephen Gottschalk, Brandon Triplett, Jason N. Johnson

Institutions: St. Jude Children's Research Hospital, University of Tennessee Health Science Center, Cincinnati Children's Hospital Medical Center

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Award: Novel therapeutic gene editing to induce fetal hemoglobin for sickle cell disease

OpenAlex ID: W4396562385

FWCI: 1.371

Cites: 26

Cited by: 6

Related to: 10