Work

Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo

Year: 2024

Type: article

Abstract: Neuronal local circuits in the olfactory bulb are modulated by centrifugal long circuits. In vivo study here shows that inhibitory horizontal limb of the diagonal band of Broca (HDB) modulates all five types of mitral/tufted cells (M/TCs), by direct inhibitory circuits HDB → M/TCs and indirect disinhibitory long circuits HDB → interneurons → M/TCs. The HDB net effect exerts excitation in all types of M/TCs but more powerful in deeper layer output neurons as HDB activation frequency increases, which may sharpen the tuning specificity of classes of M/TCs to odors during sensory processing.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00078.2024

Authors: Adam C. Puche, Chelsea Hook, Fu-Wen Zhou

Institution: University of Maryland, Baltimore

Language: English

Topic: Olfactory and Sensory Function Studies

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funder: National Institute on Deafness and Other Communication Disorders

Awards: G138624478, G2249811245