Figure S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Year: 2024
Type: other
Abstract: Knockdown or knockout of Cdkn2a in mouse melanoma cell lines increases sensitivity to multiple anti-folates but not to de novo pyrimidine synthesis; Knockdown of RB1 does not recapitulate the anti-folate response exhibited by shp16 cells. Related to Figure 3.
Authors: Naveen Kumar Tangudu, Raquel Buj, Hui Wang, Jiefei Wang, Aidan R. Cole, Apoorva Uboveja, Richard Fang, Amandine Amalric, Baixue Yang, Adam Chatoff, Claudia V. Crispim, Peter Sajjakulnukit, Maureen A. Lyons, Kristine Cooper, Nadine Hempel, Costas A. Lyssiotis, Uma R. Chandran, Nathaniel W. Snyder, Katherine M. Aird
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4396578446