FIGURE 5 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Year: 2024
Type: other
Abstract: shp16 tumors are more sensitive to the antifolate methotrexate. A and B, SKMEL28 human melanoma cells were infected with lentivirus expressing a shRNA targeting GFP (shCont) or p16 (shp16). A total of 107 cells were subcutaneously implanted into athymic nude mice. Mice were treated with vehicle controls or methotrexate (MTX). Individual tumor growth curves in shp16 tumors (A) and shCont tumors (B). Shown are growth rates ± SE. Linear mixed-model group comparisons: shp16 versus shCont P < 0.001; shCont: MTX versus vehicle P = 0.734; shp16: MTX versus vehicle P = 0.031; (shp16: MTX vs. vehicle) versus (Control: vehicle vs. MTX) P = 0.002.
Authors: Naveen Kumar Tangudu, Raquel Buj, Hui Wang, Jiefei Wang, Aidan R. Cole, Apoorva Uboveja, Richard Fang, Amandine Amalric, Baixue Yang, Adam Chatoff, Claudia V. Crispim, Peter Sajjakulnukit, Maureen A. Lyons, Kristine Cooper, Nadine Hempel, Costas A. Lyssiotis, Uma R. Chandran, Nathaniel W. Snyder, Katherine M. Aird
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4396578501