Kidney collecting duct-derived vasopressin is not essential for appropriate concentration or dilution of urine
Year: 2024
Type: article
Abstract: Hypothalamic vasopressin is required for appropriate urinary concentration. However, whether collecting duct-derived vasopressin is involved remains unknown. We developed a novel transgenic mouse model to induce tissue-specific deletion of vasopressin and showed that collecting duct-derived vasopressin is not required to concentrate or dilute urine.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, Robert Wood Johnson Foundation, ASN Foundation for Kidney Research, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, Common Fund
Awards: G1187429744, G1281419676, G1290154072, G1362895741, Mechanisms of EGFR Activation and Signaling in Kidney Disease, G1433450062, Renal Biology and Disease Training Program, G2532530556, G3141307551, Vanderbilt O'Brien Kidney Center, Medical Scientist Training Program, G4702718958, Prune Belly Syndrome: Mechanisms of Filamin A Mutations, G5820162814, G6444718951, G7938664385, Vanderbilt Stimulating Access to Research in Residency (V-StARR), The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation, Rac1 and the actin cytoskeleton in renal tubular repair, cis-regulation of RNA polymerase pausing , WNK-SPAK signaling in the Distal Nephron, Understanding the physiology and pathophysiology of kidney-derived vasopressin, Innovative therapeutic approaches to treat chronic kidney disease, The Laminin Receptors in Kidney Disease, Role of the innate immune system in acute kidney injury, Medical Scientist Training Program
OpenAlex ID: W4396585930