Year: 2024
Type: article
Study design: Observational Study
Abstract: The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.
Source: Nature Communications
Authors: Jamirah Nazziwa, Eva Freyhult, Mun-Gwan Hong, Emil Johansson, Filip Årman, Jonathan Hare, Kamini Gounder, Melinda Rezeli, Tirthankar Mohanty, Sven Kjellström, Anatoli Kamali, Etienne Karita, William Kilembe, Matt A. Price, Pontiano Kaleebu, Susan Allen, Eric Hunter, Thumbi Ndung’u, Jill Gilmour, Sarah L. Rowland-Jones, Eduard Sanders, Amin S. Hassan, Joakim Esbjörnsson
Institutions: Lund University, Uppsala University, Science for Life Laboratory, National Bioinformatics Infrastructure Sweden, Stockholm University, International AIDS Vaccine Initiative, Imperial College London, Africa Health Research Institute, University College London, University of KwaZulu-Natal, University of California, San Francisco, MRC/UVRI & LSHTM Uganda Research Unit, Uganda Virus Research Institute, Emory University, Ragon Institute of MGH, MIT and Harvard, University of Oxford, Kenya Medical Research Institute, Aurum Institute, KEMRI-Wellcome Trust Research Programme, Aga Khan University Nairobi
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,790
Funders: United States Agency for International Development, International AIDS Vaccine Initiative, Wellcome Trust, Lunds Universitet, Svenska Sällskapet för Medicinsk Forskning, Vetenskapsrådet, National Institutes of Health, Medical Research Council, Medicinska Fakulteten, Lunds Universitet, National Institute of Allergy and Infectious Diseases
Awards: G1097787405, The discriminatory ability of pre-treatment HIV-1 low frequency drug resistance variants to predict antiretroviral treatment outcomes, Characterization of hyperacute HIV infection in adults and infants to increase the understanding of HIV pathogenesis and opportunities for prevention, Viral Pathogens, G4137015471, Sub-Saharan African Network for TB/HIV research Excellence (SANTHE), Spatiotemporal gene expression in secondary lymphoid tissue during hyperacute hiv infection, Virologic Correlates of Heterosexual Transmission, Deciphering the impact of sex in early subtype C HIV infection and during HART
OpenAlex ID: W4405091147