Year: 2026
Type: article
Abstract: We disclose a new platform for C(sp3)-directed C–H annulations to generate valuable heterocycles from readily available starting materials. A commercially available one carbon linchpin is leveraged to access alkyl boron species from simple anilines. Rhodium-catalyzed C(sp3) transmetallation from this key intermediate provides a C–Rh bond appropriately positioned for ortho-C–H activation, enabling formation of C,C-rhodacycles. With the addition of a variety of alkyne coupling partners, diverse dihydroquinolines are synthesized.
Source: Organic Chemistry Frontiers
DOI: 10.1039/d6qo01119e
Institution: Emory University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Awards: G135240269, OCE-PRF Track 1: Biological Mercury Hotspots: The Role of Phytoplankton Blooms in Nearshore Marine Mercury Bioaccumulation, Innovation in Catalyst and Oxidative Amination Reaction Development for the Synthesis of Darobactin and Other Ribosomally Synthesized Post-translationally Modified Peptides (RiPPs), G5739541517, Graduate Research Fellowship Program (GRFP)
OpenAlex ID: W7214728353