Influence of gender on periodontal outcomes: A retrospective analysis of eight randomized clinical trials
Year: 2024
Type: article
Abstract: AIMS: To explore the influence of gender on periodontal treatment outcomes in a dataset of eight RCTs conducted in Brazil, United States, and Germany. METHODS: Clinical parameters were compared between men and women with stages III/IV grades B/C generalized periodontitis at baseline and 1-year post-therapy, including scaling and root planing with or without antibiotics. RESULTS: Data from 1042 patients were analyzed. Men presented a tendency towards higher probing depth (p = .07, effect size = 0.11) and clinical attachment level (CAL) than women at baseline (p = .01, effect size = 0.16). Males also presented statistically significantly lower CAL gain at sites with CAL of 4-6 mm at 1-year post-therapy (p = .001, effect size = 0.20). Among patients with Grade B periodontitis who took antibiotics, a higher frequency of women achieved the endpoint for treatment (i.e., ≤4 sites PD ≥5 mm) at 1 year than men (p < .05, effect size = 0.12). CONCLUSION: Men enrolled in RCTs showed a slightly inferior clinical response to periodontal therapy in a limited number of sub-analyses when compared to women. These small differences did not appear to be clinically relevant. Although gender did not dictate the clinical response to periodontal treatment in this population, our findings suggest that future research should continue to explore this topic.
Source: Journal of Periodontal Research
DOI: 10.1111/jre.13272
Authors: Nidia Castro dos Santos, Miriam R. Westphal, Belen Retamal‐Valdes, Poliana Mendes Duarte, Luciene Cristina Figueiredo, Marcelo Faveri, Jamil Shibli, Geisla Soares, Tamires Miranda, Daiane Fermiano, Ivan Borges, Cristiane Goncalves, Caio Junji Tanaka, Flavia Teles, Max Goodson, Hatice Hasturk, Thomas Van Dyke, Benjamin Ehmke, Peter Eickholz, Katrin Nickles, Ulrich Schlagenhauf, Joerg Meyle, Thomas Kocher, Ti‐Sun Kim, Helio Doyle, Magda Feres
Institutions: Guarulhos University, The Forsyth Institute, University of Florida, Universidade Federal do Paraná, Universidade São Judas Tadeu, Estácio (Brazil), University of Pennsylvania, University Hospital Münster, Goethe University Frankfurt, Universitätsklinikum Würzburg, Justus-Liebig-Universität Gießen, Universitätsmedizin Greifswald, University Hospital Heidelberg, Harvard University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
Funders: Deutsches Krebsforschungszentrum, Deutsche Forschungsgemeinschaft, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institutes of Health, National Institute of Dental and Craniofacial Research
Awards: Associação de antibioticoterapia e do controle químico da placa supragengival ao tratamento periodontal mecânico: avaliação clínica e microbiológica, Clinical and microbiological influence of the dose and duration of systemic antibiotics in the treatment of chronic periodontitis., G4455276591, Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations, G9000153324, G9000174125
OpenAlex ID: W4396659938