FIGURE 7 from Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity
Year: 2024
Type: other
Abstract: Survival time is reduced in huNBSGW PDX models. A, huNBSGW PDX3, 9, and 18 were engrafted with the same pooled donor CD34+ cells. Survival time was PDX dependent with PDX3 and 9 having a shorter survival time compared with PDX18. Survival curves are significantly different between huPDX and non-huPDX for all three PDX models (P < 0.025, log-rank test). For all PDX models, n = 3 mice/group for huPDX and non-huPDX. B, Solid tumor mass (in grams) of huPDX and non-huPDX at necropsy. Bars are the average tumor burden, error bars are SEM. Measures for individual mice are shown as black dots (n = 2–3 per group). C, Ascites fluid volume at necropsy. The ascites fluid volume trended higher in non-huPDX for PDX3 and PDX9, but was only significantly different for PDX9. Statistical analysis for B and C used unpaired t tests to compare huPDX versus non-huPDX values for each PDX line.
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4396660540