Work

Update on human herpesvirus 7 pathogenesis and clinical aspects as a roadmap for future research

Year: 2024

Type: review

Abstract: ABSTRACT Human herpesvirus 7 (HHV-7) is a common virus that is associated with various human diseases including febrile syndromes, dermatological lesions, neurological defects, and transplant complications. Still, HHV-7 remains one of the least studied members of all human betaherpesviruses. In addition, HHV-7-related research is mostly confined to case reports, while in vitro or in vivo studies unraveling basic virology, transmission mechanisms, and viral pathogenesis are sparse. Here, we discuss HHV-7-related literature linking clinical syndromes to the viral life cycle, epidemiology, and viral immunopathogenesis. Based on our review, we propose a hypothetical model of HHV-7 pathogenesis inside its host. Furthermore, we identify important knowledge gaps and recommendations for future research to better understand HHV-7 diseases and improve therapeutic interventions.

Source: Journal of Virology

DOI: 10.1128/jvi.00437-24

Authors: Rianne Verbeek, Linos Vandekerckhove, Jolien Van Cleemput

Institution: Ghent University

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Fonds Wetenschappelijk Onderzoek, Vlaamse regering