FIGURE 2 from Small Extracellular Vesicles Promote Stiffness-mediated Metastasis
Year: 2024
Type: other
Abstract: EV cargo is affected by matrix stiffness. A, Schematic of EV secretion by cancer cells on standard plastic, tumor (25 kPa) stiffness and normal tissue (0.5 kPa) stiffness. B, Silver stain of EV isolated proteins. C, Clustergram of EV protein abundance values. The color scale corresponds to the log2 normalized z-scored abundance values scaled to −2 and 2 for visual clarity. Three biological repeats. See also Supplementary Table S2. D, Gene ontology pathway analysis using Metascape for MDA-MB-231 EV proteins enriched in stiff EVs over soft EVs (79). Three biological repeats.
Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Praful R. Nair, Carolyn Marar, Najwa Faqih, Gabrielle E. Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M. Lewis, Hanna Hong, Michelle N. Karl, Raghav Vij, Gabriella C. Russo, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Muñoz-Barrutia, Luo Gu, T.S. Karin Eisinger-Mathason, Denis Wirtz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4396770023